Synthesis of some triazolyl-antipyrine derivatives and investigation of analgesic activity
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol.36, no.7-8, pp.685-689, 2001 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 36 Issue: 7-8
- Publication Date: 2001
- Doi Number: 10.1016/s0223-5234(01)01252-1
- Journal Name: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Page Numbers: pp.685-689
- Keywords: antipyrine, triazoles, analgesic activity
- Anadolu University Affiliated: No
Abstract
The synthesis of some triazolyl-antipyrine derivatives starting from 4-chloroacetamidoantipyrine and 3-(aryloxyalkyl)-4-ethyl/phenyl-5-mercapto-1,2,4-triazoles is described. The chemical structures of the compounds were elucidated by IR, H-1-NMR and mass spectral studies. These compounds were tested for analgesic activity. (C) 2001 Editions scientifiques et medicales Elsevier SAS.