Latest Research about Active Pharmaceutical Ingredient Loaded Poly Lactic Acid-co-Glycolic Acid (PLGA) based Drug Delivery System in Türkiye

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Kaval B., Şen F. D., Batmaz K. K., Ekinci M., Öztürk A. A.

European Journal of Life Sciences, vol.1, pp.127-139, 2023 (Peer-Reviewed Journal)

  • Publication Type: Article / Review
  • Volume: 1
  • Publication Date: 2023
  • Journal Name: European Journal of Life Sciences
  • Page Numbers: pp.127-139
  • Anadolu University Affiliated: Yes


Some of the most well-engineered and produced biomaterials are polyesters based on polyglycolic acid (PGA), polylactic acid (PLA), and their copolymers, polylactic acid co-glycolic acid (PLGA). In controlled release systems, PLGA is the most extensively used and popular polymer. Because of its biodegradability, biocompatibility, and favorable release kinetics, but also because of the reliability of protein delivery issues, this synthetic polymer has been found to be very successful. PLGA is approved in various human drug delivery systems by EMA and FDA. In this review, first, PLGA and historical development, usage, physico- chemical structure, drug release properties, degredation specifications, solubility, crystallinity, thermal stability, release properties, types of PLGA will be mentioned. In the last stage of the review, studies conducted in Türkiye are included. In conclusion, we believe that this review is a resource for researchers doing research with PLGA.