Determination of carbamazapine by flow-injection analysis: Its application to tablet analysis and dissolution studies

Comoglu T., Gonul N., ŞENER E., Dal A. G., Tuncel M.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, no.18, pp.2677-2690, 2006 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2006
  • Doi Number: 10.1080/10826070600923225
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2677-2690
  • Keywords: carbamazepine, flow-injection analysis, tablet analysis, dissolution studies, analytical method validation, HPLC analysis, PERFORMANCE LIQUID-CHROMATOGRAPHY, HUMAN PLASMA, MASS-SPECTROMETRY, CARBAMAZEPINE, METABOLITES, DRUGS, COLUMN, PHENYTOIN, SERUM, HPLC
  • Anadolu University Affiliated: Yes


Flow injection analysis (FIA) of carbamazepine (CBZ) and its relevant application to the conventional CBZ tablets, e. g., content uniformity test and tablet dissolution, is described in this study. An aqueous solution of 1% sodium dodecyl sulphate (SDS) was employed as a carrier solvent. The best parameters were determined for FIA analysis; flow-rate of 1 mL (.) min(-1), detection wavelength of 288 nm, and an injection volume of 20 mL. Validation tests (intra- and inter-day) were realized with highly good repeatability (RSD% = 1.92) and linearity, limit of detection (LOD) and limit of quantification (LOQ) were calculated to be 8.34 x 10(-7) Mand 2.5 x 10(-6) M, respectively. Results of analysis which were achieved on the tablets were compared to those methods that were suggested by USP 28. Each step was examined by statistical testing, and it seems that the proposed method is applicable, as well as the methods in the pharmacopoeia.