Basal and histamine-induced gastric acid secretion in alloxan diabetic rats
General Pharmacology, cilt.24, sa.1, ss.121-126, 1993 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 1
- Basım Tarihi: 1993
- Doi Numarası: 10.1016/0306-3623(93)90021-o
- Dergi Adı: General Pharmacology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.121-126
- Anadolu Üniversitesi Adresli: Evet
Özet
1. 1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach. © 1993.