Basal and histamine-induced gastric acid secretion in alloxan diabetic rats

ÖZÇELİKAY A. T., ALTAN V. M., Yildizoǧlu-Ari N., Altinkurt O., ONUR F., ÖZTÜRK Y.

General Pharmacology, cilt.24, sa.1, ss.121-126, 1993 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 1
  • Basım Tarihi: 1993
  • Doi Numarası: 10.1016/0306-3623(93)90021-o
  • Dergi Adı: General Pharmacology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.121-126
  • Anadolu Üniversitesi Adresli: Evet

Özet

1. 1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach. © 1993.