Basal and histamine-induced gastric acid secretion in alloxan diabetic rats

ÖZÇELİKAY A. T., ALTAN V. M., Yildizoǧlu-Ari N., Altinkurt O., ONUR F., ÖZTÜRK Y.

General Pharmacology, vol.24, no.1, pp.121-126, 1993 (SCI-Expanded) identifier identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 1
  • Publication Date: 1993
  • Doi Number: 10.1016/0306-3623(93)90021-o
  • Journal Name: General Pharmacology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.121-126
  • Anadolu University Affiliated: Yes

Abstract

1. 1. Effects of alloxan-induced diabetes on the rat gastric acid secretion were investigated using a number of biostatistical models described earlier. 2. 2. Histamine-induced gastric acid secretion was found to be decreased in alloxan-diabetic rats when compared with their age-matched controls. 3. 3. Basal acid secretion was also decreased depending on experimentally-induced diabetes. 4. 4. The above results strongly suggest that alloxan-induced diabetes depresses vagal activity and H2-receptor activity in the stomach. © 1993.