New antibacterial steroidal alkaloids from Sarcococca brevifolia

Jayasinghe U., Nadeem M., Atta-Ur-Rahman A., Choudhary M., Ratnayake H., Amtul Z.

NATURAL PRODUCT LETTERS, vol.12, no.2, pp.103-109, 1998 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 12 Issue: 2
  • Publication Date: 1998
  • Doi Number: 10.1080/10575639808048277
  • Journal Name: NATURAL PRODUCT LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.103-109
  • Keywords: steroidal alkaloids, Sarcococca brevifolia, pregnane, epipachysamine-E-5-ene-4one, N-b-demethylepipachysamine-E-5-ene-4-one, iso-N-formylchonemorphine, antibacterial
  • Anadolu University Affiliated: No

Abstract

Three new steroidal alkaloids, epipachysamine-E-5-ene-4-one (1), N(b-)demethylepipachysamine-E-5-ene-4-one (2) and iso-N-formylchonemorphine (3) have been isolated from Sarcococca brevifolia. Structures of these compounds were determined by spectroscopic studies. Compounds 1 and 3 exhibited strong antibacterial activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Corynebacterium diphtheriae and Pseudomonas aeruginosa.