New antibacterial steroidal alkaloids from Sarcococca brevifolia

Jayasinghe U., Nadeem M., Atta-Ur-Rahman A., Choudhary M., Ratnayake H., Amtul Z.

NATURAL PRODUCT LETTERS, cilt.12, sa.2, ss.103-109, 1998 (SCI-Expanded, Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Sayı: 2
  • Basım Tarihi: 1998
  • Doi Numarası: 10.1080/10575639808048277
  • Dergi Adı: NATURAL PRODUCT LETTERS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.103-109
  • Anahtar Kelimeler: steroidal alkaloids, Sarcococca brevifolia, pregnane, epipachysamine-E-5-ene-4one, N-b-demethylepipachysamine-E-5-ene-4-one, iso-N-formylchonemorphine, antibacterial
  • Anadolu Üniversitesi Adresli: Hayır

Özet

Three new steroidal alkaloids, epipachysamine-E-5-ene-4-one (1), N(b-)demethylepipachysamine-E-5-ene-4-one (2) and iso-N-formylchonemorphine (3) have been isolated from Sarcococca brevifolia. Structures of these compounds were determined by spectroscopic studies. Compounds 1 and 3 exhibited strong antibacterial activity against Bacillus cereus, Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Proteus mirabilis, Corynebacterium diphtheriae and Pseudomonas aeruginosa.