Solanum vegetable-based diets improve impairments in memory, redox imbalance, and altered critical enzyme activities in Drosophila melanogaster model of neurodegeneration

Ogunsuyi O. B., Oboh G., ÖZEK G., GÖGER F.

JOURNAL OF FOOD BIOCHEMISTRY, vol.45, no.3, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.1111/jfbc.13150
  • Journal Name: JOURNAL OF FOOD BIOCHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), Biotechnology Research Abstracts, Business Source Elite, Business Source Premier, CAB Abstracts, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Veterinary Science Database
  • Keywords: African eggplant, black nightshade, fruit fly, functional foods, neurotoxicity, OXIDATIVE STRESS, ANTIOXIDANT PROPERTIES, MONOAMINE-OXIDASE, ALUMINUM TOXICITY, CHOLINESTERASE, ALKALOIDS, POLYPHENOLS, ALZHEIMERS, INHIBITION, EXPOSURE
  • Anadolu University Affiliated: Yes

Abstract

The effects of two Solanum vegetables, S. macrocarpon L. (African eggplant), and S. nigrum L. (black nightshade) on aluminum model of neurodegeneration in Drosophila melanogaster was investigated. Flies were treated with AlCl3 alone or in combination with the leaves from both samples in their diets for 7 days. Thereafter, locomotor performance and aversive phototaxic suppression test for learning and memory were carried out. This was followed by assay for reactive oxygen species, antioxidant properties, and enzyme (monoamine oxidase and cholinesterase) activities. Also, the in vitro antioxidant properties and chromatographic phenolic and alkaloid characterization of the samples were determined. Results showed that impaired behavioral physiology, antioxidant status, and enzyme activities observed in Al-treated flies were ameliorated in flies treated with both samples. In addition, both samples exhibited in vitro antioxidant effects. The protective effects from these samples against Al-induced toxicity can be associated with their antioxidant, antimonoaminergic, and anticholinergic properties. Practical applications In the quest for a holistic prevention/management approach to neurodegenerative diseases, functional foods are becoming prominent. The use of Drosophila melanogaster to study human diseases is gaining huge recognition due to the high homologue between disease-causing genes between the two organisms. Consequently, this study presents African eggplant and black nightshade leafy vegetables as sources of polyphenols and alkaloids which are able to ameliorate impaired learning and memory, redox status, and enzyme activities in Al-induced D. melanogaster model of neurodegeneration.