Anti-Angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid

KOPARAL A. T.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences, cilt.70, sa.5-6, ss.159-164, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 70 Sayı: 5-6
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1515/znc-2014-4178
  • Dergi Adı: Zeitschrift fur Naturforschung - Section C Journal of Biosciences
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.159-164
  • Anahtar Kelimeler: Cladonia foliacea, Letharia vulpina, (-)-usnic acid, vulpinic acid, USNIC ACID, CYTOTOXIC ACTIVITIES, CELLS, METABOLITES, GROWTH, MECHANISMS, APOPTOSIS, A549
  • Anadolu Üniversitesi Adresli: Evet

Özet

The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT assay. The anti-Angiogenic potential of the substances was determined by the endothelial tube formation assay. Both lichen substances exhibited strong anti-Angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-Angiogenic substance because of its low cytotoxicity and stronger anti-Angiogenic activity on the HUVEC cell line.