Anti-Angiogenic and antiproliferative properties of the lichen substances (-)-usnic acid and vulpinic acid

KOPARAL A. T.

Zeitschrift fur Naturforschung - Section C Journal of Biosciences, vol.70, no.5-6, pp.159-164, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 70 Issue: 5-6
  • Publication Date: 2015
  • Doi Number: 10.1515/znc-2014-4178
  • Journal Name: Zeitschrift fur Naturforschung - Section C Journal of Biosciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.159-164
  • Keywords: Cladonia foliacea, Letharia vulpina, (-)-usnic acid, vulpinic acid, USNIC ACID, CYTOTOXIC ACTIVITIES, CELLS, METABOLITES, GROWTH, MECHANISMS, APOPTOSIS, A549
  • Anadolu University Affiliated: Yes

Abstract

The anti-proliferative activities of the lichen substances (-)-usnic acid and vulpinic acid on the viability of HepG2 hepatocarcinoma cells, NS20Y neuroblastoma cells and HUVEC endothelial cells were studied by the MTT assay. The anti-Angiogenic potential of the substances was determined by the endothelial tube formation assay. Both lichen substances exhibited strong anti-Angiogenic activity and were more cytotoxic to the cancer cell lines than to the normal cell line, but vulpinic acid has more potential as an anti-Angiogenic substance because of its low cytotoxicity and stronger anti-Angiogenic activity on the HUVEC cell line.