Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease

TÜRKAN F., Taslimi P., SALTAN F. Z.

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, cilt.33, sa.8, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 8
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1002/jbt.22340
  • Dergi Adı: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: anticholinergics, antidiabetic, enzyme inhibition, metabolic enzymes, tannic acid, GLUTATHIONE-S-TRANSFERASE, ALPHA-GLUCOSIDASE INHIBITORS, CARBONIC-ANHYDRASE, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, LACTOPEROXIDASE, EXPRESSION, APOPTOSIS, PHENOLICS, EFFICACY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Multiple studies have been recorded on the synthesis and design of multi-aim anti-Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer's disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), alpha-glycosidase, alpha-amylase, and butyrylcholinesterase (BChE). IC50 values of tannic acid obtained 11.9 nM against alpha-glycosidase and 3.3 nM against alpha-amylase, respectively. In contrast, K-i values were found of 50.96 +/- 2.18 mu M against AChE and 53.17 +/- 4.47 mu M against BChE. alpha-Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.