Tannic acid as a natural antioxidant compound: Discovery of a potent metabolic enzyme inhibitor for a new therapeutic approach in diabetes and Alzheimer's disease
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, vol.33, no.8, 2019 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 33 Issue: 8
- Publication Date: 2019
- Doi Number: 10.1002/jbt.22340
- Journal Name: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Keywords: anticholinergics, antidiabetic, enzyme inhibition, metabolic enzymes, tannic acid, GLUTATHIONE-S-TRANSFERASE, ALPHA-GLUCOSIDASE INHIBITORS, CARBONIC-ANHYDRASE, ACETYLCHOLINESTERASE, BUTYRYLCHOLINESTERASE, LACTOPEROXIDASE, EXPRESSION, APOPTOSIS, PHENOLICS, EFFICACY
- Anadolu University Affiliated: Yes
Abstract
Multiple studies have been recorded on the synthesis and design of multi-aim anti-Alzheimer molecules. Using dual butyrylcholinesterase/acetylcholinesterase inhibitor molecules has attracted more interest in the therapy for Alzheimer's disease. In this study, a tannic acid compound showed excellent inhibitory effects against acetylcholine esterase (AChE), alpha-glycosidase, alpha-amylase, and butyrylcholinesterase (BChE). IC50 values of tannic acid obtained 11.9 nM against alpha-glycosidase and 3.3 nM against alpha-amylase, respectively. In contrast, K-i values were found of 50.96 +/- 2.18 mu M against AChE and 53.17 +/- 4.47 mu M against BChE. alpha-Glycosidase inhibitor compounds can be utilized as a novel group of antidiabetic drugs. By competitively decreasing glycosidase activity, these inhibitor molecules help to hamper the fast breakdown of sugar molecules and thereby control the blood sugar level.