Two new polyhydroxylated pentacyclic triterpenes with cytotoxic activities from Manilkara pellegriniana (Sapotaceae)

Mogue L. D., Ango P. Y., Fotso G. W., Mapitse R., Kapche D. W., Karaosmanoğlu O., ...Daha Fazla

Phytochemistry Letters, cilt.31, ss.161-165, 2019 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 31
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.phytol.2019.04.002
  • Dergi Adı: Phytochemistry Letters
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.161-165
  • Anahtar Kelimeler: Polyhydroxylated urs-12(13)-ene pentacyclic triterpenes, Sapotaceae, Manilkara pellegriniana, Manilkara argentea, Cytotoxicity activities, DERIVATIVES
  • Anadolu Üniversitesi Adresli: Evet

Özet

© 2019Two new polyhydroxylated urs-12(13)-ene pentacyclic triterpenes namely 2α 3α 19α 20β 23-pentahydroxyurs-12-en-28-oic acid (1) and 1β 2α 3α 5, 19α 24-hexahydroxyurs-11(12), 20(30)-dien-28-oic acid (2) were isolated from the stem bark of Manilkara pellegriniana together with seven known compounds: ursolic acid 3, 1β-hydroxyeucaphic acid 4, β-Amyrin acetate 5, taraxerol 6, taraxerol acetate 7, 3α-spinasterol 8, and spinasterone 9. In addition, the chemical investigation of another specie of the same genus, M. argentea afforded six known compounds: 3β,6α,19α,23-tetrahydroxyurs-12-en-28-oic acid 10, 2α-hydroxyursolic acid 11, garbanzol 12, 3α-spinasterol glucoside 13, 3,5,7,4′,5′-pentahydroxyflavan 14, and (+)-proto-quercitol 15. Their structures were established from spectral data, mainly HRESIMS, 1D NMR and 2D NMR and by comparison with literature data. The cytotoxicity activities of compounds 1 and 2 as well as doxorubicin were evaluated on four cancer cell lines. Compound 1 had significant cytotoxic effect towards SPC212 lung cancer cells with IC50 value of 0.52 μM.