In this study, meteorological time series from five meteorological stations in and around a watershed in Turkey were used in the statistical downscaling of global climate model results to be used for future projections. Two general circulation models (GCMs), Canadian Climate Center (CGCM3.1(T63)) and Met Office Hadley Centre (2012) (HadCM3) models, were used with three Special Report Emission Scenarios, A1B, A2, and B2. The statistical downscaling model SDSM was used for the downscaling. The downscaled ensembles were put to validation with GCM predictors against observations using nonparametric statistical tests. The two most important meteorological variables, temperature and precipitation, passed validation statistics, and partial validation was achieved with other time series relevant in hydrological studies, namely, cloudiness, relative humidity, and wind velocity. Heat waves, number of dry days, length of dry and wet spells, and maximum precipitation were derived from the primary time series as annual series. The change in monthly predictor sets used in constructing the multiple regression equations for downscaling was examined over the watershed and over the months in a year. Projections between 1962 and 2100 showed that temperatures and dryness indicators show increasing trends while precipitation, relative humidity, and cloudiness tend to decrease. The spatial changes over the watershed and monthly temporal changes revealed that the western parts of the watershed where water is produced for subsequent downstream use will get drier than the rest and the precipitation distribution over the year will shift. Temperatures showed increasing trends over the whole watershed unparalleled with another period in history. The results emphasize the necessity of mitigation efforts to combat climate change on local and global scales and the introduction of adaptation strategies for the region under study which was shown to be vulnerable to climate change.