NANOSTRUCTURED LIPID CARRIER AS A NOVEL INSIGHT FOR ORAL BIOAVAILABILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS


Barre L., Kaynak M. S.

Recent Advances in Medicine and Health Sciences: Concepts, Researches and Practice, Nazmi Duran,Feray Aydın, Editör, Livre de Lyon, Lyon, ss.275-290, 2023

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2023
  • Yayınevi: Livre de Lyon
  • Basıldığı Şehir: Lyon
  • Sayfa Sayıları: ss.275-290
  • Editörler: Nazmi Duran,Feray Aydın, Editör
  • Anadolu Üniversitesi Adresli: Evet

Özet

Lipid carriers consist of various structural and functional traits pliable to modification attained by adjusting lipid composition such as triglyceride oils, mixed glycerides, polar oils, and other additives (2). Lipid-based drug delivery systems have become increasingly prominent due to their potential to enhance the solubility and bioavailability of poorly soluble drugs (3). These systems are widely accepted, commercially viable, and can be customized to meet various product requirements. Lipid systems offer high stability, high carrier capacity, and can incorporate both hydrophilic and hydrophobic substances. These approaches can also be administered via different routes, including oral, topical, parenteral, and pulmonary, making them versatile drug carriers for challenging pharmaceutical molecules (4).