In this study artificial neural network (ANN) models have been designed to predict the ring cotton yam properties from the fiber properties measured on HVI (high volume instrument) system and the performance of ANN models have been compared with our previous statistical models based on regression analysis. Yarn count, twist and roving properties were selected as input variables as they give significant influence on yarn properties. In experimental part, a total of 180 cotton ring spun yarns were produced using 15 different blends. The four yarn counts and three twist multipliers were chosen within the range of Ne 20-35 and alpha(e) 3.8-4.6 respectively. After measuring yarn tenacity and breaking elongation, evaluations of data were performed by using ANN. Afterwards, sensitivity analysis results and coefficient of multiple determination (R-2) values of ANN and regression models were compared. Our results show that ANN is more powerful tool than the regression models.