A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into Their Anticancer Potencies

SEVER B., ALTINTOP M. D., AKALIN ÇİFTÇİ G., ÖZDEMİR A.

MEDICINAL CHEMISTRY, vol.17, no.10, pp.1104-1128, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 10
  • Publication Date: 2021
  • Doi Number: 10.2174/1573406416666201021142832
  • Journal Name: MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, Chemical Abstracts Core, EMBASE, MEDLINE
  • Page Numbers: pp.1104-1128
  • Keywords: Triazolothiadiazine, indole, colorectal cancer, non-small cell lung cancer, apoptosis, cell cycle arrest, COX-2, CYCLOOXYGENASE-2, INHIBITION, AKT
  • Anadolu University Affiliated: Yes

Abstract

Background: Targeted therapies acting on specific molecular targets in cancer cells with better curative efficacy and lower toxicity have come into prominence for the management of non-small cell lung cancer (NSCLC) and colorectal cancer (CRC). COX-2 stands out as a plausible target for anticancer agents due to its pivotal role in tumor initiation, progression and invasion.