Determination of parabens in pharmaceutical and cosmetic products by capillary electrophoresis

Uysal U. D., Gueray T.

JOURNAL OF ANALYTICAL CHEMISTRY, vol.63, no.10, pp.982-986, 2008 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 63 Issue: 10
  • Publication Date: 2008
  • Doi Number: 10.1134/s1061934808100109
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.982-986
  • Anadolu University Affiliated: Yes


A validated capillary electrophoresis method for the determination of parabens-methyl, ethyl, propyl, and butyl is described. The optimum results were obtained by the use of a run buffer containing 20 mM borate buffer (pH 9.0) with 10% methanol and by applying a voltage of 20 kV, a low hydrodynamic injection of 10 s, and detecting the signals at 200 nm. Moxifloxazin was used as an internal standard. All parabens were separated within 10 min. The method showed a good repeatability, linearity, and sensitivity. It was applied to the determination of parabens in pharmaceutical and certain cosmetic products.