LINEAR MODELING OF THE EFFECT OF INTRAVENOUS HISTAMINE INFUSION ON RAT GASTRIC-ACID SECRETION - A BIOSTATISTICAL EVALUATION BY SPLITTING THE TIME-EFFECT CURVES

ÖZTÜRK Y., ÖZÇELİKAY A. T., ALTAN V., ALTINKURT O.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, vol.13, no.7, pp.463-469, 1991 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 7
  • Publication Date: 1991
  • Journal Name: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.463-469
  • Keywords: LINEAR REGRESSION, GASTRIC ACID SECRETION, HISTAMINE, BIOSTATISTICAL MODELING, ISOLATED STOMACH, RECEPTORS, DOGS
  • Anadolu University Affiliated: Yes

Abstract

Lumen perfusion experiments have been widely employed for the evaluation of gastric acid secretion in rats. The advantage of the lumen perfusion models is the simplicity in evaluating the effectiveness of secretagogues and antisecretagogues. There is, however, no efficient methodology for biostatistical modeling of gastric acid secretion in lumen-perfused rats. In order to optimize methodology, we applied a linear regression model after splitting the time-effect curves obtained from histamine-induced gastric acid secretion in rats.