LINEAR MODELING OF THE EFFECT OF INTRAVENOUS HISTAMINE INFUSION ON RAT GASTRIC-ACID SECRETION - A BIOSTATISTICAL EVALUATION BY SPLITTING THE TIME-EFFECT CURVES

ÖZTÜRK Y., ÖZÇELİKAY A. T., ALTAN V., ALTINKURT O.

METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY, cilt.13, sa.7, ss.463-469, 1991 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 7
  • Basım Tarihi: 1991
  • Dergi Adı: METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.463-469
  • Anahtar Kelimeler: LINEAR REGRESSION, GASTRIC ACID SECRETION, HISTAMINE, BIOSTATISTICAL MODELING, ISOLATED STOMACH, RECEPTORS, DOGS
  • Anadolu Üniversitesi Adresli: Evet

Özet

Lumen perfusion experiments have been widely employed for the evaluation of gastric acid secretion in rats. The advantage of the lumen perfusion models is the simplicity in evaluating the effectiveness of secretagogues and antisecretagogues. There is, however, no efficient methodology for biostatistical modeling of gastric acid secretion in lumen-perfused rats. In order to optimize methodology, we applied a linear regression model after splitting the time-effect curves obtained from histamine-induced gastric acid secretion in rats.