New antidepressant drug candidate: Hypericum montbretti extract

CAN Ö. D., Ismail I. B., ÖZTÜRK Y., ÖZTÜRK N., POTOĞLU ERKARA İ., Sagratini G., ...Daha Fazla

NATURAL PRODUCT RESEARCH, cilt.25, sa.15, ss.1469-1472, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 15
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1080/14786419.2011.557800
  • Dergi Adı: NATURAL PRODUCT RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1469-1472
  • Anahtar Kelimeler: Hypericum, rutin, modified forced swimming test, tail suspension, Rota-Rod, antidepressant, quercitrin, RUTIN
  • Anadolu Üniversitesi Adresli: Evet

Özet

This study was designed to investigate possible antidepressant-like effects of the extract prepared from the flowers of Hypericum montbretti Spach. (Guttiferae, Clusiaceae). Phytochemical constituents of the methanolic extract were analysed by HPLC method. The main flavonoid component was detected as rutin, and another highly concentrated phenolic compound was quercitrin. Antidepressant activity of the extract was examined by tail suspension and modified forced swimming tests, whereas the motor coordination of the animals was tested by the Rota-Rod apparatus. Reboxetine at a dose of 20 mg kg(-1) was used as a reference drug. Dose-dependent antidepressant activity was observed in both tests following the administration of extract at 100 and 250 mg kg(-1) doses. To the best of our knowledge, this is the first study reporting the antidepressant activity of H. montbretti extract. Additionally, the results of this work support previous papers reporting the antidepressant activity of rutin.