Synthesis and anti-cancer activity evaluation of new aurone derivatives

Demirayak S., Yurttaş L., Gündoğdu-Karaburun N., Karaburun A. Ç., Kayagil I.

Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.30, sa.5, ss.816-825, 2015 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 5
  • Basım Tarihi: 2015
  • Doi Numarası: 10.3109/14756366.2014.976568
  • Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.816-825
  • Anahtar Kelimeler: Anti-cancer activity, aurone, benzofuranone, NCI, synthesis, ALLOSTERIC INHIBITORS, DESIGN, DISCOVERY, FLAVONES, SCAFFOLD, CHROMONE, IDENTIFY, SPECTRA, FLOWERS, SERIES
  • Anadolu Üniversitesi Adresli: Evet

Özet

© 2015 Informa UK Ltd. All rights reserved.In this study, we have synthesized 2-[3- or 4-(2-aryl-2-oxoethoxy)arylidene]benzofuran-3-one derivatives (D1-D38) and evaluated their anti-cancer activities. The final compounds were obtained in multistep synthesis reactions using benzofuranon-3-one derivatives (A1-A4, B) as starting materials which were gained in various synthetic ways. Aurone derivatives (C1-C10) were acquired with the condensation reaction of these starting materials and 3-/4-hydroxybenzaldehyde which were then reacted with α-bromoacetophenones to get final compounds. The anti-cancer activity of the selected compounds was performed by National Cancer Institute (NCI), USA against 60 human tumor cell lines derived from nine neoplastic diseases. Compounds exhibited anti-cancer activity in varying ratios.