Simple method of paroxetine determination using a single channel FIA with no in-line reaction process

Altiokka G., Kircali K.

ANALYTICAL SCIENCES, vol.19, no.4, pp.629-631, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2003
  • Doi Number: 10.2116/analsci.19.629
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.629-631
  • Anadolu University Affiliated: No


A flow-injection analysis (FIA) of paroxetine hydrochloride (PRX), a selective serotonin reuptake inhibitor (SSRI) currently used as an antidepressant drug, is described. A 0.1 mol dm(-3) acetate buffer at pH 3.07 was found to be the best solvent. The analyte was detected at 293 nm. The calibration equation was linear over the range of 1.07 X 10(-6) to 5.35 x 10(-6) mol dm(-3). The limit of detection (LOD) and the limit of quantitation (LOQ) were 3.2 x 10(-7) and 9.5 x 10(-7) mol dm(-3), respectively. The proposed method was applied to the determination of PRX in pharmaceutical preparations. The results were compared with those obtained by a conventional batchwise UV-spectrophotometry.