Development of nano-sized ketoprofen lysine incorporated Eudragit® S100 nanomedicine by double emulsion solvent evaporation and in vitro characterization
Journal of Pharmacy and Pharmacognosy Research, cilt.7, sa.1, ss.47-58, 2019 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 7 Sayı: 1
- Basım Tarihi: 2019
- Dergi Adı: Journal of Pharmacy and Pharmacognosy Research
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.47-58
- Anahtar Kelimeler: Eudragit® S100, Ketoprofen lysine, Nanoparticle
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Anadolu Üniversitesi Adresli: Evet
Özet
Context: Pain has a very important effect on the biological, psychological, sociological and economic situation of a patient. Nanoparticles (NPs) are being extensively investigated as drug delivery systems worldwide for pharmaceutical applications.
Aims: To design and compare the release characteristics of sustained-release formulations of ketoprofen lysine (KL) NPs.
Methods: KL-Eudragit® S100 NPs were produced by double emulsion solvent evaporation method. The physicochemical characteristics of NPs were studied.
Results: Particle size of NPs prepared was in the range of 99 and 141 nm. Encapsulation efficiency (%) was obtained (76%) for NP formulations prepared. Weibull models were determined to be the most appropriate kinetic models for NP containing KL. KL-loaded NPs demonstrated nanostructural character and NPs showed extended release of KL.
Conclusions: NPs developed were found to be stable and representing a promising system for sustained delivery of KL.