Development of nano-sized ketoprofen lysine incorporated Eudragit® S100 nanomedicine by double emulsion solvent evaporation and in vitro characterization

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Öztürk A. A., Çinar N. İ., Yenilmez E.

Journal of Pharmacy and Pharmacognosy Research, vol.7, no.1, pp.47-58, 2019 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 1
  • Publication Date: 2019
  • Journal Name: Journal of Pharmacy and Pharmacognosy Research
  • Journal Indexes: Scopus
  • Page Numbers: pp.47-58
  • Keywords: Eudragit® S100, Ketoprofen lysine, Nanoparticle
  • Anadolu University Affiliated: Yes

Abstract

Context: Pain has a very important effect on the biological, psychological, sociological and economic situation of a patient. Nanoparticles (NPs) are being extensively investigated as drug delivery systems worldwide for pharmaceutical applications.

Aims: To design and compare the release characteristics of sustained-release formulations of ketoprofen lysine (KL) NPs.

Methods: KL-Eudragit® S100 NPs were produced by double emulsion solvent evaporation method. The physicochemical characteristics of NPs were studied.

Results: Particle size of NPs prepared was in the range of 99 and 141 nm. Encapsulation efficiency (%) was obtained (76%) for NP formulations prepared. Weibull models were determined to be the most appropriate kinetic models for NP containing KL. KL-loaded NPs demonstrated nanostructural character and NPs showed extended release of KL.

Conclusions: NPs developed were found to be stable and representing a promising system for sustained delivery of KL.