Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats

CAN Ö. D., ÖZTÜRK Y., ÖZTÜRK N., Sagratini G., Ricciutelli M., Vittori S., ...More

FITOTERAPIA, vol.82, no.4, pp.576-584, 2011 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 82 Issue: 4
  • Publication Date: 2011
  • Doi Number: 10.1016/j.fitote.2011.01.008
  • Journal Name: FITOTERAPIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.576-584
  • Keywords: St. John's Wort, Hypericum perforatum, Diabetes mellitus, Rutin, Tail pinch, Tail flick, NEUROPATHIC PAIN, IN-VITRO, MECHANICAL HYPERALGESIA, MEDIATED INHIBITION, RUTIN, NEURONS, ANTIOXIDANT, ALLODYNIA, BEHAVIOR, EXTRACT
  • Anadolu University Affiliated: Yes

Abstract

This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week administrations of SJW extract (125 and 250 mg/kg) induced significant decrease in high blood glucose levels of three weeks STZ-diabetic rats and improved their dysregulated metabolic parameters. In addition, SJW extract treatment caused restoration in the mechanical hyperalgesia of diabetic animals. These findings provide a rationale for the traditional use of SJW against diabetes and display the potential of this plant as a new drug candidate/source for the treatment of diabetic pain. (C) 2011 Elsevier B.V. All rights reserved.