Effects of treatment with St. John's Wort on blood glucose levels and pain perceptions of streptozotocin-diabetic rats

CAN Ö. D., ÖZTÜRK Y., ÖZTÜRK N., Sagratini G., Ricciutelli M., Vittori S., ...Daha Fazla

FITOTERAPIA, cilt.82, sa.4, ss.576-584, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 82 Sayı: 4
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.fitote.2011.01.008
  • Dergi Adı: FITOTERAPIA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.576-584
  • Anahtar Kelimeler: St. John's Wort, Hypericum perforatum, Diabetes mellitus, Rutin, Tail pinch, Tail flick, NEUROPATHIC PAIN, IN-VITRO, MECHANICAL HYPERALGESIA, MEDIATED INHIBITION, RUTIN, NEURONS, ANTIOXIDANT, ALLODYNIA, BEHAVIOR, EXTRACT
  • Anadolu Üniversitesi Adresli: Evet

Özet

This present study was undertaken to examine treating effects of St. John's Wort (SJW) extract on nociceptive perception of STZ-diabetic animals based on its potential antidiabetic and antinociceptive activities. One week administrations of SJW extract (125 and 250 mg/kg) induced significant decrease in high blood glucose levels of three weeks STZ-diabetic rats and improved their dysregulated metabolic parameters. In addition, SJW extract treatment caused restoration in the mechanical hyperalgesia of diabetic animals. These findings provide a rationale for the traditional use of SJW against diabetes and display the potential of this plant as a new drug candidate/source for the treatment of diabetic pain. (C) 2011 Elsevier B.V. All rights reserved.