Genetic polymorphisms in preoperative myocardial infarction

Senol S., Es M. U., Gokmen G., Ercin O., Tuylu B. A., Kargun K.

Asian Cardiovascular and Thoracic Annals, cilt.23, sa.4, ss.389-393, 2015 (Scopus) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 4
  • Basım Tarihi: 2015
  • Doi Numarası: 10.1177/0218492314547724
  • Dergi Adı: Asian Cardiovascular and Thoracic Annals
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.389-393
  • Anahtar Kelimeler: Coronary artery disease, Methylenetetrahydrofolate reductase (MTHFR), Myocardial infarction, Plasminogen activator inhibitor 1, Polymorphism, single nucleotide
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objective: This study compared plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677Tand A1298C polymorphisms in patients with myocardial infarction with ST-segment elevation before undergoing to coronary artery bypass grafting, and in patients who had previously undergone coronary artery bypass grafting. Method: Seventy patients with myocardial infarction with ST-segment elevation, scheduled to undergo coronary artery bypass grafting, were included in the study group, and 70 patients who had previously undergone coronary artery bypass grafting were included in the control group. Genetic polymorphisms were determined using real-time polymerase chain reaction methods. Results: Our data showed that there were no significant differences in plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms or allele frequencies between the 2 groups. Conclusion: Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase C677T and A1298C polymorphisms were not associated risk factors in patients who had myocardial infarction with ST-segment elevation and planned to have coronary artery bypass grafting.