In vitro antibacterial and antibiotic modifying activity of crude extract, fractions and 3 ', 4 ', 7-trihydroxyflavone from Myristica fragrans Houtt against MDR Gram-negative enteric bacteria

Dzotam J. K., Simo I. K., Bitchagno G., ÇELİK İ., Sandjo L. P., Tane P., ...More

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE, vol.18, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 18
  • Publication Date: 2018
  • Doi Number: 10.1186/s12906-018-2084-1
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Keywords: 3 ',4 ',7-trihydroxyflavone, Antibiotic modifying activity, Cameroon, Gram-negative bacteria, Multidrug-resistance, Myristica fragrans, ANTIMICROBIAL ACTIVITY, NATURAL-PRODUCTS, STEM BARK, ANTIOXIDANT
  • Anadolu University Affiliated: Yes


Background: Nutmeg is the seed kernel inside the fruit of Myristica fragrans Houtt. (Myristicaceae). It possesses various pharmacological activities but is used in Cameroon only for its flavor in making cakes. The present study thus aimed to investigate the in vitro antibacterial activity and antibiotic modifying activities of crude seed kernel methanol extract (MFS), fractions (MFSa-e) as well as 3',4',7-trihydroxyflavone from Myristica fragrans against a panel of multi-drug resistant (MDR) Gram-negative bacteria.