The electrochemical oxidation of Mn(II) acetate to Mn(III) acetate, which is an industrial oxidizing agent and catalyst, in acetic acid medium was investigated in a bipolar packed-bed electrode cell with mesh spacers. The simplex method was used for optimization. The experiments were carried out in two groups as batch and continuous processes. The chemical conversion ratio, chosen as the objective function was found to be 94.0% in batch process and 92.4% in continuous process under optimum conditions by considering the performance factors such as the current efficiency, the space-time yield and the energy consumption. These results showed the effectiveness of the simplex method. (C) 2004 Elsevier B.V. All rights reserved.