Electrochemical Investigation of Interactions between Potential DNA Targeted Compounds, 2,4-Di- and 2,3,4-Trisubstituted Benzimidazo[1,2-a]pyrimidines and Nucleic Acid

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Caliskan A., KARADENİZ H., MERİÇ A., ERDEM GÜRSAN K. A.

ANALYTICAL SCIENCES, vol.26, no.1, pp.117-120, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.2116/analsci.26.117
  • Journal Name: ANALYTICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.117-120
  • Anadolu University Affiliated: Yes

Abstract

The electrochemical aspects of interactions between DNA and two organic compounds are discussed herein. Potential DNA targeted compounds, 2-methyl-4-phenyl-benzo[4,5]imidazo[1,2-a]pyrimidine (C1) and 2,3,4-trimethyl-benzo[4,5]imidazo[1,2-a]pyrimidine (C2), were synthesized and their cytotoxic and/or growth inhibitory effects were studied previously. Disposable sensor technology was used to explore the interaction between the compounds and nucleic acid, such as fish sperm DNA at the electrode surface and in the solution phase. The changes upon encountering oxidation signals of electroactive DNA base-guanine and these compounds were monitored electrochemically.