Is N-acetyl cysteine protective against monocrotaline-induced toxicity?


Karagoz S., ILGIN S., ATLI EKLİOĞLU Ö., Perk B. O., BURUKOĞLU DÖNMEZ D., ERGUN B., ...More

TOXIN REVIEWS, vol.32, no.3, pp.47-54, 2013 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Review
  • Volume: 32 Issue: 3
  • Publication Date: 2013
  • Doi Number: 10.3109/15569543.2013.809547
  • Journal Name: TOXIN REVIEWS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.47-54
  • Keywords: Glutathione, hepatotoxicity, monocrotaline, N-acetyl cysteine, pulmonary toxicity, INDUCED PULMONARY-HYPERTENSION, ACETAMINOPHEN-INDUCED HEPATOTOXICITY, HEPATIC VENOOCCLUSIVE DISEASE, ENDOTHELIAL-CELL INJURY, PYRROLIZIDINE ALKALOIDS, LIVER INFLAMMATION, LIPID-PEROXIDATION, OXIDATIVE DAMAGE, RAT MODEL, ACETYLCYSTEINE
  • Anadolu University Affiliated: Yes

Abstract

Monocrotaline (MCT) is a pyrrolizidine alkaloid which induces cardio-pulmonary toxicity and hepatotoxicity in animals and humans. MCT is frequently ingested because of food grain contamination accidentally or in the form of herbal medicine preparations. The aim of this study was to observe the protective effect of N-acetyl cysteine (NAC) on MCT-induced pulmonary toxicity and hepatotoxicity. According to our results (right ventricular pressures [RVPs], ratios of right ventricle (RV)/heart weight (HW), plasma AST levels, liver glutathione levels, liver MDA levels and liver histopathological examinations of groups), protective effects were observed with NAC treatment in both MCT-induced pulmonary toxicity and hepatotoxicity.