Research Information System
Phosphorus, Sulfur and Silicon and the Related Elements, vol.200, no.10, pp.763-772, 2025 (SCI-Expanded, Scopus)
The threat of infectious diseases to human health is still increasing today. It is difficult to treat microbial infections successfully because microorganisms are resistant to antimicrobial drugs, which increases the mortality rate in cases with comorbidities. The discovery of new therapeutic drugs to treat microbial infections has become increasingly important in recent years. In this study, based on the antimicrobial activities of benzothiazoles and hydrazones, 4-[((5-chlorobenzothiazole/benzothiazol-2-yl)thio)methyl]-N’-(alkyl/arylmethylene)benzohydrazide derivatives (3a–3j) was synthesized, and the antimicrobial activity was evaluated against various microorganisms. IR, MS,1H-NMR, and 13C-NMR spectroscopic techniques were used to clarify the structures of the compounds. The tested compounds exhibited weak activity against gram-positive and gram-negative bacteria as well as fungi. The cytotoxic activities of the compounds were also investigated on the NIH/3T3 healthy cell line and the A549 tumor cell line, and it was determined that compound 3g showed the highest cytotoxic activity against A549 cells. Molecular docking studies demonstrated favorable binding affinities of these derivatives with bacterial DNA gyrase B (GyrB) and topoisomerase IV (ParE) subunits, suggesting their mechanism of antibacterial action. Additionally, in silico pharmacokinetic analysis using predicted promising drug-like properties, despite some compounds exhibiting limited water solubility.