New chroman-4-one/thiochroman-4-one derivatives as potential anticancer agents

Demirayak Ş., Yurttaş L., Gündoğdu-Karaburun N., Karaburun A. Ç., Kayağil İ.

SAUDI PHARMACEUTICAL JOURNAL, cilt.25, sa.7, ss.1063-1072, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 7
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1016/j.jsps.2017.04.040
  • Dergi Adı: SAUDI PHARMACEUTICAL JOURNAL
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1063-1072
  • Anahtar Kelimeler: Chromanone, Thiochromanone, Benzopyranone, Benzothiopyranone, Flavone, alpha, beta-Unsaturated carbonyl, Anticancer activity, IN-VITRO, ANTIPROLIFERATIVE ACTIVITY, CYTOTOXIC ACTIVITY, BENZIMIDAZOLE DERIVATIVES, BIOLOGICAL EVALUATION, AROMATASE INHIBITORS, DRUG DISCOVERY, ANALOGS, CHALCONES, DESIGN
  • Anadolu Üniversitesi Adresli: Evet

Özet

The synthesis of 3-[3/4-(2-aryl-2-oxoethoxy) arylidene] chroman/thiochroman-4-one derivatives (1-34) and evaluation of their anticancer activities were aimed in this work. Final compounds were obtained in multistep synthesis reactions using phenol/thiophenol derivatives as starting materials. For anticancer activity evaluation, all compounds were offered to National Cancer Institute (NCI), USA and selected ones were tested against sixty human tumor cell lines derived from nine neoplastic diseases. The activity results were evaluated according to the drug screening protocol of the institute. Compounds containing thiochromanone skeleton exhibited higher anticancer activity. (C) 2017 The Authors. Production and hosting by Elsevier B.V. on behalf of King Saud University.