The Influence of Some Nonsteroidal Anti-inflammatory Drugs on Metabolic Enzymes of Aldose Reductase, Sorbitol Dehydrogenase, and alpha-Glycosidase: a Perspective for Metabolic Disorders

Demir Y., Duran H. E., DURMAZ L., Taslimi P., BEYDEMİR Ş., GÜLÇİN İ.

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY, vol.190, no.2, pp.437-447, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 190 Issue: 2
  • Publication Date: 2020
  • Doi Number: 10.1007/s12010-019-03099-7
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, PASCAL, Agricultural & Environmental Science Database, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, Compendex, EMBASE, Food Science & Technology Abstracts, MEDLINE, Pollution Abstracts, Veterinary Science Database
  • Page Numbers: pp.437-447
  • Keywords: Nonsteroidal anti-inflammatory drugs, Enzyme inhibition, alpha-Glycosidase, Aldose reductase, Sorbitol dehydrogenase, IN-VITRO ANTIOXIDANT, GLUCOSIDASE INHIBITORS, BIOLOGICAL EVALUATION, CRYSTAL-STRUCTURE
  • Anadolu University Affiliated: Yes


Pain, as a sensible alarm signal of living organisms to avoid tissue damage, is a common and debilitating consequence of a lot of disorders and diseases. The management of chronic pain is particularly challenging. For pain treatment, many analgesic drugs are used for their therapeutic effects. In this study, some nonsteroidal anti-inflammatory drugs including etofenamate, meloxicam, diclofenac, and tenoxicam were tested against alpha-glycosidase from Saccharomyces cerevisiae, sorbitol dehydrogenase (SDH), and aldose reductase (AR) enzymes from sheep liver. Nonsteroidal anti-inflammatory drugs demonstrated useful inhibition properties against alpha-glycosidase, AR, and SDH enzymes. K-i values were found in the range of 11.93 +/- 3.77-364.88 +/- 40.01 mu M for alpha-glycosidase, 3.36 +/- 1.08 mu M-17.68 +/- 3.39 mM for AR, and 1.68 +/- 0.02 mu M-30.98 +/- 14.31 mM for SDH. They can be selective drugs as antidiabetic agents, because of their inhibitory properties against SDH, alpha-glycosidase, and AR enzymes.