Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents

ACAR ÇEVİK U., SAĞLIK B. N., Ardic C. M., ÖZKAY Y., ATLI EKLİOĞLU Ö.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, vol.43, no.2, pp.151-158, 2018 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1515/tjb-2017-0167
  • Journal Name: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.151-158
  • Keywords: Benzimidazole, Hydrazone, Cytotoxic activity, BIOLOGICAL EVALUATION, POTENTIAL ANTICANCER, ACYLHYDRAZONE DERIVATIVES, ANTITUMOR AGENTS, DESIGN, CYTOTOXICITY
  • Anadolu University Affiliated: Yes

Abstract

Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer anticancer drugs remains critically important. From this point of view, in the present study benzimidazole-hydrazone derivatives were synthesized by aiming at the identification of new chemical entities as potent anticancer agents.