Synthesis and evaluation of new benzimidazole derivatives with hydrazone moiety as anticancer agents

ACAR ÇEVİK U., SAĞLIK B. N., Ardic C. M., ÖZKAY Y., ATLI EKLİOĞLU Ö.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.43, sa.2, ss.151-158, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 43 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1515/tjb-2017-0167
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.151-158
  • Anahtar Kelimeler: Benzimidazole, Hydrazone, Cytotoxic activity, BIOLOGICAL EVALUATION, POTENTIAL ANTICANCER, ACYLHYDRAZONE DERIVATIVES, ANTITUMOR AGENTS, DESIGN, CYTOTOXICITY
  • Anadolu Üniversitesi Adresli: Evet

Özet

Objectives: Cancer is one of the leading causes of death throughout the world. Current therapy options suffer from the major limitations of side effects and drug resistance. Thus, continuing search for newer and safer anticancer drugs remains critically important. From this point of view, in the present study benzimidazole-hydrazone derivatives were synthesized by aiming at the identification of new chemical entities as potent anticancer agents.