Synthesis and analgesic activities of some 2-(benzazolylacetyl)amino-3-ethoxycarbonylthiophene derivatives

Demirayak S., Karaburun A., Kayagil I., Ucucu U., Beis R.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, cilt.180, sa.8, ss.1841-1848, 2005 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 180 Sayı: 8
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1080/104265090889503
  • Dergi Adı: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.1841-1848
  • Anahtar Kelimeler: analgesic activity, benzazole, thiophene, PHARMACOLOGICAL INVESTIGATIONS
  • Anadolu Üniversitesi Adresli: Hayır

Özet

In this study, some 2-[2-(benzazole-2-thioxy)acetylamino]-3-ethoxycai-bonylthiophene and 2-[2-(benzazole-1-yl)acetylamino]-3-ethoxycarbonylthiophene compounds were obtained by the reaction of 2-chloroacetylamino-3-ethoxycarbonylthiophene derivatives and a suitable benzazole-2-thione or benzimidazole derivatives. Analgesic activities of the compounds were tested by using tail-flick and tail-immersion methods. It is reported that some of the compounds showed remarkable analgesic activities.