Synthesis and analgesic activities of some 2-(benzazolylacetyl)amino-3-ethoxycarbonylthiophene derivatives
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.180, no.8, pp.1841-1848, 2005 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 180 Issue: 8
- Publication Date: 2005
- Doi Number: 10.1080/104265090889503
- Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
- Page Numbers: pp.1841-1848
- Keywords: analgesic activity, benzazole, thiophene, PHARMACOLOGICAL INVESTIGATIONS
- Anadolu University Affiliated: No
Abstract
In this study, some 2-[2-(benzazole-2-thioxy)acetylamino]-3-ethoxycai-bonylthiophene and 2-[2-(benzazole-1-yl)acetylamino]-3-ethoxycarbonylthiophene compounds were obtained by the reaction of 2-chloroacetylamino-3-ethoxycarbonylthiophene derivatives and a suitable benzazole-2-thione or benzimidazole derivatives. Analgesic activities of the compounds were tested by using tail-flick and tail-immersion methods. It is reported that some of the compounds showed remarkable analgesic activities.