Synthesis and analgesic activities of some 2-(benzazolylacetyl)amino-3-ethoxycarbonylthiophene derivatives

Demirayak S., Karaburun A., Kayagil I., Ucucu U., Beis R.

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, vol.180, no.8, pp.1841-1848, 2005 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 180 Issue: 8
  • Publication Date: 2005
  • Doi Number: 10.1080/104265090889503
  • Journal Name: PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Page Numbers: pp.1841-1848
  • Keywords: analgesic activity, benzazole, thiophene, PHARMACOLOGICAL INVESTIGATIONS
  • Anadolu University Affiliated: No

Abstract

In this study, some 2-[2-(benzazole-2-thioxy)acetylamino]-3-ethoxycai-bonylthiophene and 2-[2-(benzazole-1-yl)acetylamino]-3-ethoxycarbonylthiophene compounds were obtained by the reaction of 2-chloroacetylamino-3-ethoxycarbonylthiophene derivatives and a suitable benzazole-2-thione or benzimidazole derivatives. Analgesic activities of the compounds were tested by using tail-flick and tail-immersion methods. It is reported that some of the compounds showed remarkable analgesic activities.