Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways

CAN Ö. D., ALYU ALTINOK F., Turan N., ÖZDEMİR A.

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.13, sa.5, ss.411-417, 2016 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 13 Sayı: 5
  • Basım Tarihi: 2016
  • Doi Numarası: 10.2174/1570180812666150819003950
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.411-417
  • Anahtar Kelimeler: Antinociceptive, 4,5-dihydro-1H-pyrazole, hot-plate, rota-rod, tail-clip, writhing, BEARING BENZENE SULFONAMIDE, BIOLOGICAL EVALUATION, 1,3,5-TRISUBSTITUTED PYRAZOLINES, PHARMACOLOGICAL EVALUATION, ANTICANCER AGENTS, ANALGESIC AGENTS, MICE, MOIETIES, RATS, PAIN
  • Anadolu Üniversitesi Adresli: Evet

Özet

This study was planned to investigate possible antinociceptive activity of 1,5-diaryl-3-[4-(methylsulfonyl) phenyl]-4,5-dihydro-1H-pyrazole derivatives (2a-s), based on the analgesia-inducing potential of 4,5-dihydro-1H-pyrazole moiety carrying compounds. Tail-clip and hot-plate tests, measuring centrally organized responses to a noxious stimulus, were performed in order to examine antinociceptive potential of the test compounds (100 mg/kg, i.p). In addition, peripherally mediated antinociceptive effect was evaluated by acetic acid-induced writhing tests. Motor coordination of the animals was tested in a Rota-rod apparatus.