Antinociceptive Activities of Some 4,5-Dihydro-1H-Pyrazole Derivatives: Involvement of Central and Peripheral Pathways

CAN Ö. D., ALYU ALTINOK F., Turan N., ÖZDEMİR A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.13, no.5, pp.411-417, 2016 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 5
  • Publication Date: 2016
  • Doi Number: 10.2174/1570180812666150819003950
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.411-417
  • Keywords: Antinociceptive, 4,5-dihydro-1H-pyrazole, hot-plate, rota-rod, tail-clip, writhing, BEARING BENZENE SULFONAMIDE, BIOLOGICAL EVALUATION, 1,3,5-TRISUBSTITUTED PYRAZOLINES, PHARMACOLOGICAL EVALUATION, ANTICANCER AGENTS, ANALGESIC AGENTS, MICE, MOIETIES, RATS, PAIN
  • Anadolu University Affiliated: Yes

Abstract

This study was planned to investigate possible antinociceptive activity of 1,5-diaryl-3-[4-(methylsulfonyl) phenyl]-4,5-dihydro-1H-pyrazole derivatives (2a-s), based on the analgesia-inducing potential of 4,5-dihydro-1H-pyrazole moiety carrying compounds. Tail-clip and hot-plate tests, measuring centrally organized responses to a noxious stimulus, were performed in order to examine antinociceptive potential of the test compounds (100 mg/kg, i.p). In addition, peripherally mediated antinociceptive effect was evaluated by acetic acid-induced writhing tests. Motor coordination of the animals was tested in a Rota-rod apparatus.