New pyrazoline derivatives and their antidepressant activity

KAPLANCIKLI Z. A., ÖZDEMİR A., Turan-Zitouni G., ALTINTOP M. D., CAN Ö. D.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, cilt.45, sa.9, ss.4383-4387, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 9
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.ejmech.2010.06.011
  • Dergi Adı: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Index Chemicus (IC)
  • Sayfa Sayıları: ss.4383-4387
  • Anahtar Kelimeler: Triazole, Pyrazoline, Antidepressant activity, Modified forced swimming test, Tail suspension tests, Rota-Rod, FORCED SWIMMING TEST, MICE, DEPRESSION, INHIBITORS, RECEPTORS, DRUG
  • Anadolu Üniversitesi Adresli: Evet

Özet

Some triazolo-pyrazoline derivatives were synthesized to investigate their potential antidepressant activities. The chemical structures of the compounds were elucidated by IR, NMR and FAB(+)-MS spectral data and elemental analyses. Antidepressant-like activities of the test compounds (100 mg/kg) were screened using both modified forced swimming and tail suspension tests. Rota-Rod test was performed for the examination of probable neurological deficits due to the test compounds, which may interfere with the test results. The test compounds in the series exhibited different levels of antidepressant activities when compared to reference drug fluoxetine. None of the test compounds changed motor coordination of animals when assessed in the Rota-Rod test. Therefore, experimental results in this study were not interfered with motor abnormalities. (C) 2010 Elsevier Masson SAS. All rights reserved.