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DEMİRAYAK Ş., Kayagil I., YURTTAŞ L., Aslan R.
Journal of Enzyme Inhibition and Medicinal Chemistry, vol.25, no.1, pp.74-79, 2010 (SCI-Expanded)
Article / Article
Journal of Enzyme Inhibition and Medicinal Chemistry
Science Citation Index Expanded (SCI-EXPANDED), Scopus
1,5-diarylimidazole-2-thione, 3-pyrazoline-5-one, antinociceptive activity, anticancer activity, BIOLOGICAL EVALUATION, SELECTIVE INHIBITORS, CYCLOOXYGENASE-2 INHIBITORS, COX-2, POTENT, DESIGN, SERIES, IDENTIFICATION, SUBSTITUENTS, APOPTOSIS
Anadolu University Affiliated:
In this study, some 4-(1,5-diarylimidazol-2-yl)thioacetyl-1-phenyl-2,3- dimethyl-3-pyrazoline-5-one derivatives were prepared by reacting 4-(2-chloroacetyl)-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one and 2-mercapto-1, 5-diarylimidazole derivatives. The antinociceptive and anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, 2a, 2d, 2g, and 2j, showed remarkable antinociceptive activity, and one of the compounds, 2i, showed weak anticancer activity. © 2010 Informa UK Ltd.