Synthesis of some imidazolyl-thioacetyl-pyrazolinone derivatives and their antinociceptive and anticancer activitiesal

DEMİRAYAK Ş., Kayagil I., YURTTAŞ L., Aslan R.

Journal of Enzyme Inhibition and Medicinal Chemistry, cilt.25, sa.1, ss.74-79, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 1
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3109/14756360903016751
  • Dergi Adı: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.74-79
  • Anahtar Kelimeler: 1,5-diarylimidazole-2-thione, 3-pyrazoline-5-one, antinociceptive activity, anticancer activity, BIOLOGICAL EVALUATION, SELECTIVE INHIBITORS, CYCLOOXYGENASE-2 INHIBITORS, COX-2, POTENT, DESIGN, SERIES, IDENTIFICATION, SUBSTITUENTS, APOPTOSIS
  • Anadolu Üniversitesi Adresli: Evet

Özet

In this study, some 4-(1,5-diarylimidazol-2-yl)thioacetyl-1-phenyl-2,3- dimethyl-3-pyrazoline-5-one derivatives were prepared by reacting 4-(2-chloroacetyl)-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one and 2-mercapto-1, 5-diarylimidazole derivatives. The antinociceptive and anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, 2a, 2d, 2g, and 2j, showed remarkable antinociceptive activity, and one of the compounds, 2i, showed weak anticancer activity. © 2010 Informa UK Ltd.