Synthesis of some imidazolyl-thioacetyl-pyrazolinone derivatives and their antinociceptive and anticancer activitiesal

DEMİRAYAK Ş., Kayagil I., YURTTAŞ L., Aslan R.

Journal of Enzyme Inhibition and Medicinal Chemistry, vol.25, no.1, pp.74-79, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 25 Issue: 1
  • Publication Date: 2010
  • Doi Number: 10.3109/14756360903016751
  • Journal Name: Journal of Enzyme Inhibition and Medicinal Chemistry
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.74-79
  • Keywords: 1,5-diarylimidazole-2-thione, 3-pyrazoline-5-one, antinociceptive activity, anticancer activity, BIOLOGICAL EVALUATION, SELECTIVE INHIBITORS, CYCLOOXYGENASE-2 INHIBITORS, COX-2, POTENT, DESIGN, SERIES, IDENTIFICATION, SUBSTITUENTS, APOPTOSIS
  • Anadolu University Affiliated: Yes

Abstract

In this study, some 4-(1,5-diarylimidazol-2-yl)thioacetyl-1-phenyl-2,3- dimethyl-3-pyrazoline-5-one derivatives were prepared by reacting 4-(2-chloroacetyl)-1-phenyl-2,3-dimethyl-3-pyrazoline-5-one and 2-mercapto-1, 5-diarylimidazole derivatives. The antinociceptive and anticancer activities of the compounds obtained were investigated. It was observed that some of the compounds, 2a, 2d, 2g, and 2j, showed remarkable antinociceptive activity, and one of the compounds, 2i, showed weak anticancer activity. © 2010 Informa UK Ltd.