Formulation and in-vivo evaluation of a cosmetic multiple emulsion containing vitamin C and wheat protein

Akhtar N., Yazan Y.

PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol.21, no.1, pp.45-50, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2008
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.45-50
  • Keywords: multiple emulsion, vitamin C, wheat proteins, dermatological evaluation, ASCORBIC-ACID, COLLAGEN-SYNTHESIS, SKIN FIBROBLASTS, ERYTHEMA, RELEASE
  • Anadolu University Affiliated: Yes


The purpose of the study was to see the effect of two antiaging agents in one stable multiple emulsion prepared using natural oil. Vitamin C, which is a very unstable ingredient and is decomposed in the presence of oxygen, active as an antioxidant, was entrapped in the inner aqueous phase of w/o/w multiple emulsion. In this way, slow release can be expected and the effect of vitamin C can be increased since it is protected from the external environment by entrapping it in the internal phase. The other ingredient which is a product of wheat proteins was also used as an antiaging agent in the oily phase. Both of the ingredients increase the synthesis of collagen fibers in the dermis. Therefore, a synergystic effect can be produced by using the two ingredients in one formulation.