Spectroscopic determination of acid dissociation constants of some biologically active 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

Ogretir, C; Yarligan, S; Demirayak, S

doi:10.1021/je020045a

Spectroscopic determination of acid dissociation constants of some biologically active 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

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Ogretir C., Yarligan S., Demirayak S.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, vol.47, no.6, pp.1396-1400, 2002 (SCI-Expanded)

Publication Type: Article / Article
Volume: 47 Issue: 6
Publication Date: 2002
Doi Number: 10.1021/je020045a
Journal Name: JOURNAL OF CHEMICAL AND ENGINEERING DATA
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Page Numbers: pp.1396-1400
Anadolu University Affiliated: No

Abstract

The acid dissociation constants, pK(a), of twelve biologically active 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives were determined using spectroscopic techniques. Elucidation of the structure-reactivity relationships was attempted from structural considerations based on the acid dissociation constants.