Spectroscopic determination of acid dissociation constants of some biologically active 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

Ogretir, C; Yarligan, S; Demirayak, S

doi:10.1021/je020045a

Spectroscopic determination of acid dissociation constants of some biologically active 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives

Ogretir C., Yarligan S., Demirayak S.

JOURNAL OF CHEMICAL AND ENGINEERING DATA, cilt.47, sa.6, ss.1396-1400, 2002 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 47 Sayı: 6
Basım Tarihi: 2002
Doi Numarası: 10.1021/je020045a
Dergi Adı: JOURNAL OF CHEMICAL AND ENGINEERING DATA
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.1396-1400
Anadolu Üniversitesi Adresli: Hayır

Özet

The acid dissociation constants, pK(a), of twelve biologically active 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives were determined using spectroscopic techniques. Elucidation of the structure-reactivity relationships was attempted from structural considerations based on the acid dissociation constants.