The aim of this paper is to review the use of nasal stimulants in interpersonal communication. The literature survey was performed from PubMed, ProQuest Central database of Anadolu University, and Google Scholar. Throughout history, various materials have been used as nasal stimulants to communicate and socialize intensively. Snuff is tobacco inhaled into the nostrils. It goes through the nasal mucosa into the blood and affects the neural system. Maras Powder is also a smokeless tobacco type common in the southeast of Turkey, especially in Gaziantep and Maras, which gave its name to the product. Cocaine is made from the coca plant, and it can be in the form of powder and rock. The rock one is also known as crack. It passes through the nostrils and is absorbed in the blood, causing paranoias, sleeplessness, extreme energy, and more confidence. When oxytocin is said, some positive words come to mind, such as socializing, relationships, feeling of trust, and understanding. It is a hormone and neurotransmitter. Increasing interpersonal communication in the shortest time is an important issue today. Online meetings, the ability of different people to work on the same file simultaneously over the computer, cause individuals to distance themselves from each other and decrease communication among them. Despite being in the same social environment, friends often communicate with others with their smartphones instead of having face-to-face relations. To increase interpersonal communication experience, events involving alcohol take is the mostly commonly used one. Nasal snuff, cocaine, crack, and oxytocin abolish self-control which affects interpersonal communication negatively at the end of the day.