In vitro effects of alpha-tocopherol and ascorbic acid on antioxidant characteristics of HDL

AKALIN ÇİFTÇİ G., Erdogan I., ALATAŞ İ. Ö.

TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI, cilt.36, sa.3, ss.242-247, 2011 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 3
  • Basım Tarihi: 2011
  • Dergi Adı: TURKISH JOURNAL OF BIOCHEMISTRY-TURK BIYOKIMYA DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.242-247
  • Anahtar Kelimeler: alpha-tocopherol, ascorbic acid, antioxidant HDL, VITAMIN-E, MEDIATED PEROXIDATION, DEHYDROASCORBIC ACID, PROOXIDANT, SUPPLEMENTATION, INHIBITION, PLASMA
  • Anadolu Üniversitesi Adresli: Evet

Özet

Aim: High density lipoprotein (HDL) retards accumulation of proinflammatuar oxidized phospholipids in low density lipoproteins (LDL) and have a capacity on inhibition of oxidative modification. These antioxidant and antiinflammatory properties are as important as its cholesterol efflux function on inhibition of atherosclerosis. Contrary to it's known effects when HDL has lost it's functions, gains prooxidant properties. The purpose of our study was to investigate effects of antioxidant vitamins like alpha-tocopherol and ascorbic acid on the prevention of the antioxidant characteristics of HDL against LDL oxidation in vitro.