Some pyridazinone and phthalazinone derivatives and their vasodilator activities
Archives of Pharmacal Research, vol.27, no.1, pp.13-18, 2004 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 27 Issue: 1
- Publication Date: 2004
- Doi Number: 10.1007/bf02980038
- Journal Name: Archives of Pharmacal Research
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.13-18
- Keywords: pyridazinone, phthalazinone, vasodilator activity, PLATELET-AGGREGATION, AGENTS, INHIBITORS, PHOSPHODIESTERASE
- Anadolu University Affiliated: Yes
Abstract
In this study, 6-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl)phenyl]-4,5- dihydro-3(2H)-pyridazinone and 4-[(4-arylidene-2-phenyl-5-oxoimidazolin-1-yl) phenyl]-1(2H)-phthalazinone derivatives were synthesized by reacting 6-(4-aminophenyl)-4,5-dihydro-3(2H)-pyridazinone or 4-(4-aminophenyl)-1(2H)- phthalazinone compound with different 4-arylidene-2-phenyl-5(4H)-oxazolone derivatives. The vasodilator activities of the compounds were examined both in vitro and in vivo. Some pyridazinone derivatives showed appreciable activity.