Synthesis and Antimicrobial Activity of New Pyrimidine-Hydrazones

KAPLANCIKLI Z. A., YURTTAŞ L., Turan-Zitouni G., ÖZDEMİR A., Goger G., DEMİRCİ F., ...Daha Fazla

LETTERS IN DRUG DESIGN & DISCOVERY, cilt.11, sa.1, ss.76-81, 2014 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.2174/15701808113109990037
  • Dergi Adı: LETTERS IN DRUG DESIGN & DISCOVERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.76-81
  • Anahtar Kelimeler: Pyrimidine, Hydrazone, Antimicrobial activity, DERIVATIVES, AGENTS, RESISTANCE, COMPLEXES
  • Anadolu Üniversitesi Adresli: Evet

Özet

The synthesis of twelve new pyrimidine hydrazone derivatives and subsequent evaluation of their antimicrobial activities were the aims of this present work. The intermediate product 2-[(pyrimidin-2-yl)thio]acetohydrazide was refluxed with different aromatic aldehydes/ketones in ethanol to yield N'-(arylidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide derivatives (3a-l). The structures of the compounds were elucidated by NMR, FTIR, MS, and elemental analyses. Additionally the final compounds (3a-l) were evaluated for their antimicrobial activity using a microdilution method against a panel of pathogenic Gram positive, Gram negative, and fungus strains, i.e. Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, Bacillus cereus, Bacillus subtilis, Serrratia marcescens, Staphylococcus epidermidis, and Candida utilis. Compound N'-(2-pyrilidene)-2-[(pyrimidine-5-yl)thio]acetohydrazide (3a) possessing a 2-pyridyl moiety was found to be the most active (MIC=31.25-250 mu g/mL) derivative toward the tested microorganisms.