Biological activity and chemical composition of the essential oil from the fruits of Ferula rigidula Fisch. ex DC.

İŞCAN G., KÜRKÇÜOĞLU M., TOSUN F., MİSKİ M.

Acta Pharmaceutica Sciencia, vol.61, no.3, pp.257-268, 2023 (Scopus) identifier

  • Publication Type: Article / Article
  • Volume: 61 Issue: 3
  • Publication Date: 2023
  • Doi Number: 10.23893/1307-2080.aps6117
  • Journal Name: Acta Pharmaceutica Sciencia
  • Journal Indexes: Scopus, EMBASE
  • Page Numbers: pp.257-268
  • Keywords: Antibacterial, anticandidal, essential oil, Ferula rigidula, GCMS
  • Anadolu University Affiliated: Yes

Abstract

The hydro-distilled essential oils of the fruits of F. rigidula Fisch. ex DC. was analyzed by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS) systems at the same time. Thirty-one compounds were characterized rep-resenting 98.2% of the essential oils. The main components of the oil were determined as a-pinene and camphene (24% and 20%, respectively). The anticandidal and antibacterial effects of the essential oil were determined by using partly modi-fied CLSI protocols M27-A2 and M7-A7, respectively. The essential oil of the dried fruits showed several inhibitory effects on the tested bacteria panel (MIC, 62.5 to 2000 µg/mL) and Candida species (MIC, 125 to 1000 µg/mL).