Synthesis, antibacterial and antifungal activities of 3-(1,2,4-triazol-3-yl)-4-thiazolidinones

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Ozkirimli S., Kazan F., TUNALI Y.

JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, vol.24, no.2, pp.447-452, 2009 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 24 Issue: 2
• Publication Date: 2009
• Doi Number: 10.1080/14756360802188511
• Journal Name: JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.447-452
• Keywords: 1, 2, 4-Triazole, 4-thiazolidinone, antifungal, antibacterial, DERIVATIVES, BIOSYNTHESIS, TRIAZOLE
• Anadolu University Affiliated: Yes

Abstract

A new series of 3-(1,2,4-triazol-3-yl)-4-thiazolidinone derivatives has been synthesized by the reaction of Schiff bases of 3-amino-1,2,4-triazoles with mercaptoacetic acid and 2-mercaptopropionic acid. Their antibacterial and antifungal activities were evaluated against S. aureus, S. epidermidis, C. albicans and C. glabrata.