UV spectrophotometric method for determination of the dissolution profile of rivaroxaban

Creative Commons License

ÇELEBİER M., KAYNAK M. S., Altınöz S., ŞAHİN S.

Dissolution Technologies, vol.21, no.4, pp.56-59, 2014 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.14227/dt210414p56
  • Journal Name: Dissolution Technologies
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.56-59
  • Keywords: Rivaroxaban, Tablet dissolution, UV spectroscopy, Validation
  • Anadolu University Affiliated: No

Abstract

© 2014. The United States Pharmacopeial Convention. All rights reserved.Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in pharmaceutical formulations and the amount of rivaroxaban released in tablet dissolution studies. The dissolution profile of rivaroxaban was successfully determined with the validated method.