UV spectrophotometric method for determination of the dissolution profile of rivaroxaban

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ÇELEBİER M., KAYNAK M. S., Altınöz S., ŞAHİN S.

Dissolution Technologies, cilt.21, sa.4, ss.56-59, 2014 (SCI-Expanded) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2014
  • Doi Numarası: 10.14227/dt210414p56
  • Dergi Adı: Dissolution Technologies
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.56-59
  • Anahtar Kelimeler: Rivaroxaban, Tablet dissolution, UV spectroscopy, Validation
  • Anadolu Üniversitesi Adresli: Hayır

Özet

© 2014. The United States Pharmacopeial Convention. All rights reserved.Rivaroxaban is an oral anticoagulant that is the first available orally active direct Factor Xa inhibitor. In this study, a UV spectrophotometric method was developed for the determination of rivaroxaban content in pharmaceutical formulations and the amount of rivaroxaban released in tablet dissolution studies. The dissolution profile of rivaroxaban was successfully determined with the validated method.