AQUASOMES: A NOVEL CARRIER FOR IMPROVED DRUG SOLUBILITY AND PERMEABILITY


Bwalya F., Kaynak M. S.

Recent Advances in Medicine and Health Sciences: Concepts, Researches and Practice, Nazmi Duran,Feray Aydın, Editör, Livre de Lyon, Lyon, ss.107-118, 2023

  • Yayın Türü: Kitapta Bölüm / Araştırma Kitabı
  • Basım Tarihi: 2023
  • Yayınevi: Livre de Lyon
  • Basıldığı Şehir: Lyon
  • Sayfa Sayıları: ss.107-118
  • Editörler: Nazmi Duran,Feray Aydın, Editör
  • Anadolu Üniversitesi Adresli: Evet

Özet

Aquasomes are a type of nanoparticle that can be used as a carrier system for drugs or other biomolecules (1). They are made up of three layers: an inner core layer, which helps to maintain the molecular conformation and therapeutic activity of the drug or biomolecule, and provides additional protection during transportation, coated with a carbohydrate layer, allowing for targeted drug delivery and improved stability, and an outer layer that contains the drug or biomolecule (2,3). A diagrammatic representation is shown under the preparation section. Aquasomes can be likened to “water bodies,” as their water- like characteristics safeguard and maintain biological molecules (2). Additionally, the use of aquasomes reduces the risk of side effects and ensures optimal pharmacological activity (1). Due to increased demand for safer and more effective drug delivery systems, aquasomes are a promising option not only for oral delivery which represents over half of the drugs on the market (4) but for other routes also.