Biotransformation of alpha-Cedrol and Caryophyllene Oxide by the Fungus Neurospora crassa

KIRAN İ., Durceylan Z., KIRIMER N., BAŞER K. H. C., Noma Y., DEMİRCİ F.

NATURAL PRODUCT COMMUNICATIONS, vol.5, no.4, pp.515-518, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 5 Issue: 4
  • Publication Date: 2010
  • Doi Number: 10.1177/1934578x1000500403
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.515-518
  • Keywords: Neurospora crassa, biotransformation, caryophyllene oxide, alpha-cedrol, antibacterial activity, radical scavenging activity, MICROBIAL TRANSFORMATION, (-)-CARYOPHYLLENE OXIDE, BOTRYTIS-CINEREA, HYDROXYLATION, SESQUITERPENOIDS, (+)-CEDROL, CULTURE
  • Anadolu University Affiliated: Yes


Incubation of a-cedrol and caryophyllene oxide with Neurospora crassa afforded 12 beta-hydroxy cedrol, 10 alpha-hydroxy cedrol, and 3 beta-hydroxy cedrol, and 12 beta-hydroxy caryophyllene oxide as major metabolites, respectively. The antibacterial and radical scavenging activities of the metabolites were evaluated in vitro using broth microdilution and bioauthographic techniques. However, no significant antibacterial and antioxidant activities were observed when compared with those of standard substances.