Peptidomimetics via modifications of amino acids and peptide bonds

AVAN İ., Hall C. D., Katritzky A. R.

CHEMICAL SOCIETY REVIEWS, vol.43, no.10, pp.3575-3594, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 43 Issue: 10
  • Publication Date: 2014
  • Doi Number: 10.1039/c3cs60384a
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.3575-3594
  • Anadolu University Affiliated: Yes


Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure-activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.