Peptidomimetics via modifications of amino acids and peptide bonds
CHEMICAL SOCIETY REVIEWS, cilt.43, sa.10, ss.3575-3594, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 43 Sayı: 10
- Basım Tarihi: 2014
- Doi Numarası: 10.1039/c3cs60384a
- Dergi Adı: CHEMICAL SOCIETY REVIEWS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.3575-3594
- Anadolu Üniversitesi Adresli: Evet
Özet
Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure-activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.