Peptidomimetics via modifications of amino acids and peptide bonds

AVAN İ., Hall C. D., Katritzky A. R.

CHEMICAL SOCIETY REVIEWS, cilt.43, sa.10, ss.3575-3594, 2014 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 43 Sayı: 10
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1039/c3cs60384a
  • Dergi Adı: CHEMICAL SOCIETY REVIEWS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.3575-3594
  • Anadolu Üniversitesi Adresli: Evet

Özet

Peptidomimetics represent an important field in chemistry, pharmacology and material science as they circumvent the limitations of traditional peptides used in therapy. Self-structural organizations such as turns, helices, sheets and loops can be accessed by chemical modifications of amino acids or peptides. In-depth structural and conformational analysis and structure-activity relationships (SAR) offer a way to establish peptidomimetic libraries. Herein, we review recent developments in peptidomimetics that are formed via heteroatom replacement within the native amino acid backbone. Each sub-section describes structural features, utility and preparative methods.