Research Information System
7th International Symposium on ADVANCES IN PHARMACEUTICAL ANALYSIS (APA 2025), Ankara, Turkey, 24 - 27 August 2025, pp.177-178, (Full Text)
Mucoadhesive buccal films are emerging as a convenient drug delivery system that enhances bioavailability and avoids
hepatic first pass metabolism, while providing local action and improving patient compliance. Such formulations typically
contain natural polymers such as chitosan and sodium alginate, which are capable of forming uniform, mucoadhesive films
suitable for buccal application. Chitosan, a positively charged polysaccharide, provides strong mucoadhesion and physical
robustness, while sodium alginate, a negatively charged polymer, contributes to gel formation and flexibility [1,2]. As for
the herbal component, Juniperus oxycedrus extract is one of the most widely studied herbal agents, traditionally used to
treat throat infections and oral ulcers due to its proven antimicrobial and antiinflammatory properties. The objective of the
present study was to design and characterize mucoadhesive buccal films containing J. oxycedrus extract, using different
polymeric and plasticizer matrices (low molecular weight chitosan, medium molecular weight chitosan, sodium alginate
and carboxymethyl cellulose (CMC) as polymers; glycerin (Gly) and propylene glycol (PG) as plasticizers). The films were
evaluated in terms of thickness, weight, pH, mechanical strength, and organoleptic properties to assess their suitability for
buccal application [2,3].