IMPROVEMENT IN THE DISSOLUTION PROPERTIES OF THEOPHYLLINE WITH BETA-CYCLODEXTRIN

YAZAN Y., SUMNU M.

STP PHARMA SCIENCES, cilt.4, sa.2, ss.128-132, 1994 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 4 Sayı: 2
  • Basım Tarihi: 1994
  • Dergi Adı: STP PHARMA SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.128-132
  • Anahtar Kelimeler: THEOPHYLLINE BETA-CYCLODEXTRIN INTERACTION, CO-GRINDING METHOD, FREEZE-DRYING METHOD, DISSOLUTION, PHARMACEUTICAL FORMULATIONS, INCLUSION COMPLEX, DRUG-INTERACTION, DOSAGE FORMS
  • Anadolu Üniversitesi Adresli: Hayır

Özet

An improvement in the dissolution of theophylline with beta-cyclodextrin was achieved by subjecting them to co-grinding and freeze-drying methods. The products obtained were examined by the phase solubility method, differential scanning calorimetry and X-ray diffractometry. The products thus prepared were evaluated with respect to their dissolution behaviour and particle sizes, and compared with the pure drug and the physical mixture of theophylline and beta-cyclodextrin. The improvement in the dissolution profile of theophylline in the interacted form may be due to its amorphous state, to increased wettability, or to the formation of an inclusion complex.