Induction of apoptosis and inhibition of cell proliferation by the cyclooxgenase enzyme blocker nimesulide in the Ishikawa endometrial cancer cell line

Ozalp S. S., Eren C. Y., Bostancioglu R. B., Koparal A. T.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, vol.164, no.1, pp.79-84, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 164 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.1016/j.ejogrb.2012.05.018
  • Journal Name: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.79-84
  • Keywords: Nimesulide, COX-2, Endometrial cancer, Cytotoxicity, Apoptosis, BREAST-CANCER, CYCLOOXYGENASE-2 INHIBITORS, COX-2 INHIBITOR, PROSTAGLANDIN-E, EXPRESSION, TARGET, ANGIOGENESIS, CARCINOMA, CHEMOPREVENTION, FIBROBLASTS
  • Anadolu University Affiliated: Yes

Abstract

Objectives: Endometrial cancer remains a leading cause of death in women and therefore the development of new therapies is essential. The present study evaluated the effects of nimesulide alone, cisplatin alone, and combination of cisplatin and nimesulide on an Ishikawa cell line with respect to cytotoxicity and induction of apoptosis in vitro.