Induction of apoptosis and inhibition of cell proliferation by the cyclooxgenase enzyme blocker nimesulide in the Ishikawa endometrial cancer cell line

Ozalp, S.; Eren, Ceren; Bostancioglu, Rakibe; Koparal, AYŞE

doi:10.1016/j.ejogrb.2012.05.018

Induction of apoptosis and inhibition of cell proliferation by the cyclooxgenase enzyme blocker nimesulide in the Ishikawa endometrial cancer cell line

Atıf İçin Kopyala

Ozalp S. S., Eren C. Y., Bostancioglu R. B., Koparal A. T.

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY, cilt.164, sa.1, ss.79-84, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 164 Sayı: 1
Basım Tarihi: 2012
Doi Numarası: 10.1016/j.ejogrb.2012.05.018
Dergi Adı: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.79-84
Anahtar Kelimeler: Nimesulide, COX-2, Endometrial cancer, Cytotoxicity, Apoptosis, BREAST-CANCER, CYCLOOXYGENASE-2 INHIBITORS, COX-2 INHIBITOR, PROSTAGLANDIN-E, EXPRESSION, TARGET, ANGIOGENESIS, CARCINOMA, CHEMOPREVENTION, FIBROBLASTS
Anadolu Üniversitesi Adresli: Evet

Özet

Objectives: Endometrial cancer remains a leading cause of death in women and therefore the development of new therapies is essential. The present study evaluated the effects of nimesulide alone, cisplatin alone, and combination of cisplatin and nimesulide on an Ishikawa cell line with respect to cytotoxicity and induction of apoptosis in vitro.