Cytotoxic, Apoptotic and DNA Synthesis Inhibitory Effects of Some Thiazole Derivatives

AKALIN ÇİFTÇİ G., ALTINTOP M. D., TEMEL H. E., ÖZDEMİR A., KAPLANCIKLI Z. A.

LETTERS IN DRUG DESIGN & DISCOVERY, vol.14, no.5, pp.554-566, 2017 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 14 Issue: 5
  • Publication Date: 2017
  • Doi Number: 10.2174/1570180813666160907170553
  • Journal Name: LETTERS IN DRUG DESIGN & DISCOVERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.554-566
  • Keywords: Thiazole, imidazole, triazole, cancer, DNA synthesis, apoptosis, mitochondrial membrane potential, acetylcholinesterase, butyrylcholinesterase, ANTIPROLIFERATIVE ACTIVITY, BIOLOGICAL EVALUATION, ANTICANCER, ACETYLCHOLINESTERASE, DESIGN, RESISTANCE, CARCINOMA, ANALOGS
  • Anadolu University Affiliated: Yes

Abstract

Background: Cancer is one of the leading causes of morbidity and mortality worldwide and extensive efforts have been devoted to the discovery of new anticancer agents. In the last few decades, the clinical efficacy of tiazofurin and its analogues, dasatinib and bleomycins has pointed out the importance of thiazole moiety in the field of cancer treatment.