Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

Creative Commons License

YURTTAŞ L., ÖZKAY Y., DEMİRCİ F., Goger G., Yildirim S. U., Abu Mohsen U., ...More

TURKISH JOURNAL OF CHEMISTRY, vol.38, no.5, pp.815-824, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.3906/kim-1312-62
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.815-824
  • Keywords: Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity, ANTIFUNGAL AGENTS, ANTIBACTERIAL, MYXOBACTERIA
  • Anadolu University Affiliated: Yes


Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by spectral data (IR, H-1 NMR, C-13 NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a-j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-( 4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 mu g/mL.