Synthesis, anticandidal activity, and cytotoxicity of some thiazole derivatives with dithiocarbamate side chains

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YURTTAŞ L., ÖZKAY Y., DEMİRCİ F., Goger G., Yildirim S. U., Abu Mohsen U., ...More

TURKISH JOURNAL OF CHEMISTRY, vol.38, no.5, pp.815-824, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2014
  • Doi Number: 10.3906/kim-1312-62
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.815-824
  • Keywords: Thiazole, dithiocarbamate, anticandidal activity, cytotoxicity, ANTIFUNGAL AGENTS, ANTIBACTERIAL, MYXOBACTERIA
  • Anadolu University Affiliated: Yes

Abstract

Some thiazole derivatives bearing dithiocarbamic acid esters were synthesized in order to investigate their anticandidal activity and cytotoxicity. The structures of the obtained final compounds (6a-j) were confirmed by spectral data (IR, H-1 NMR, C-13 NMR, and MS) and elemental analysis. The anticandidal activity of the compounds was determined (6a-j) using the microbroth dilution method and their cytotoxicity was evaluated according to the MTT (3-( 4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay against normal cells. Contrary to expectations, weak antifungal activity was observed with IC50 values ranging between 30 and 403 mu g/mL.